In recent times, the popularity of Selective androgen receptor modulators (SARMs) as overall wellness supplements has seen a massive surge. For years, SARM supplements have been regularly prescribed by medical practitioners across the world to treat severe and debilitating conditions such as cachexia, breast cancer, sexual dysfunction, muscle wasting, multiple sclerosis, Alzheimer’s disease, and osteoporosis to name a few.
What are Selective androgen receptor modulators?
Selective androgen receptor modulators, popularly known as SARMs, can be described as therapeutic compounds that demonstrate anabolic properties that are similar to that of anabolic-androgenic steroids. SARMs demonstrate tissue-selective activation of androgenic signaling and accentuate the presence and performance of natural hormones such as testosterone. It is important to note here that testosterone plays a vital role in the human body. It affects hematopoiesis, coagulation, psychosexual and cognitive behaviors, protein and carbohydrate metabolism, lipid, and skeletal muscle.
In recent years, SARMs have become highly popular among fitness enthusiasts because of their fat-cutting, muscle recovery, lean muscle mass-building, body strength, cardiovascular endurance, and muscle healing properties. Because of these reasons, elite athletes, bodybuilders, fitness enthusiasts, and those with physically-demanding jobs are appreciating the benefits of Selective androgen receptor modulators more than ever.
Currently, some of the most popular Selective androgen receptor modulators on the market include Ligandrol (LGD-4033), Testolone (RAD-140), GW-501516 (Cardarine), MK-677 (Ibutamoren or Nutrobal), Ostarine (MK-2866), and Andarine (S-4). It is widely estimated that there has been a significant increase in the usage of SARMs among the fitness and bodybuilding communities across the globe. This is primarily SARMs are believed to be far safer and more effective than other performance-enhancing drugs such as anabolic-androgenic steroids, prohormones, etc.
Let us now read about some of the most popular SARMs.
- Ostarine: Also known as Enobosarm or MK-2866, this nonsteroidal SARM was originally developed to treat health conditions such as osteoporosis and muscle wasting. Described as the ideal clinically characterized SARM, Ostarine allows users to lose body fat without compromising on muscle mass, size, and strength. Ostarine is commonly used along with Cardarine, MK-677, and RAD-140 in SARM cycles of 12-18 weeks.
- Ligandrol: Popularly known as LGD-4033, Ligandrol is one of the best bulking SARMs for fitness enthusiasts. This orally bioavailable SARM leads to massive gains in the levels of muscle mass, size, strength, and definition. It can also improve free and circulating testosterone levels. The use of LGD-4033 is also associated with significant gains in the levels of protein synthesis, nitrogen retention, and body strength.
- Andarine: S-4 is a popular cutting cycle SARMs supplements to lose body weight and fat. Touted as a muscle-boosting supplement, Andarine is commonly stacked with Cardarine and MK-677 to boost fat burning, lean mass, and strength. Some fitness enthusiasts even stack S-4 with Testolone and Ligandrol during a bulking SARM cycle.
- Cardarine: Sold as a cutting-edge performance-enhancer, Cardarine is one of the most sought-after peroxisome proliferator-activated receptor delta agonists (PPAR-δ). It helps get rid of stubborn abdominal and visceral fat and can regulate carbohydrate and fatty acid metabolism. Cardarine demonstrates unmatched efficacy to reduce inflammation and it also prevents muscle wasting caused by health conditions like cancer and AIDS. Fitness enthusiasts highly appreciated this performance-enhancing drug because of its ability to nurture huge, sculpted bodies. One of the biggest advantages of Cardarine is that its use is not associated with estrogenic side effects such as oily skin, fluid retention, acne, and gynecomastia. Furthermore, it doesn’t reduce sex hormones such as testosterone after the completion of a SARM cycle. It is highly effective to boost cardiovascular health, preserve muscle mass, increase body strength, and keep the liver and kidneys safe. Moreover, the use of Cardarine for 10-14 weeks is also associated with virility, vascularity, fat-burning, metabolism, energy, and better field performance.